Journal
LABORATORY INVESTIGATION
Volume 86, Issue 12, Pages 1203-1207Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/labinvest.3700488
Keywords
hematopoiesis; neoplasm; transplantation; stem cells; tumor
Categories
Ask authors/readers for more resources
There is a growing body of evidence that supports the idea that malignant tumors are initiated and maintained by a population of tumor cells that share similar biologic properties to normal adult stem cells. This model, the cancer stem cell (CSC) hypothesis, is based on the observation that tumors, like adult tissues, arise from cells that exhibit the ability to self-renew as well as give rise to differentiated tissue cells. Although the concept of the CSC is not entirely new, advances made over the past two decades in our understanding of normal stem cell biology in conjunction with the recent application of these concepts to experimentally define CSCs have resulted in the identification of CSCs in several human malignancies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available