Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
Volume 140A, Issue 23, Pages 2530-2535Publisher
WILEY-LISS
DOI: 10.1002/ajmg.a.31360
Keywords
TGF beta; Wnt; BMP4; FGF8; TVF; RUAX2; MSX1; PAX9; AXIN2; P63; Eda; dlx1; dlx2; hyopohidrotic ectodermal dysplasia; cleidocranial dysplasia; EEC syndrome; oligodontia
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More than 300 genes have so far been associated with tooth development, mainly in mouse embryos. The majority of them are associated with conserved signaling pathways mediating cellular communication, in particular between epithelial and mesenchymal tissues. Necessary functions of many signals, receptors and transcription factors have been demonstrated in mice, and mutations causing dental defects in humans have been identified in several genes. (c) 2006 Wiley-Liss, Inc.
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