Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1763, Issue 12, Pages 1364-1373Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2006.09.014
Keywords
peroxisome; glyoxysome; hydrogenosome; yeast; PEX gene; pexophagy; woronin body
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Yeast and filamentous fungi are important model organisms in microbody research. The value of these organisms as models for higher eukaryotes is underscored by the observation that the principles of various aspects of microbody biology are strongly conserved from lower to higher eukaryotes. This has allowed to resolve various peroxisome-related functions, including peroxisome biogenesis disorders in man. This paper summarizes the major advances in microbody research using fungal systems and specifies specific properties and advantages/disadvantages of the major model organisms currently in use. (c) 2006 Elsevier B.V. All rights reserved.
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