Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 17, Issue 6, Pages 607-617Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2006.11.004
Keywords
TRP; channel; splicing; calcium; diversity
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Ton channel functional diversity can be achieved at the structural level by means of three main mechanisms: (1) transcriptional regulation and processing of mRNA, (2) heteromerization of different pore-forming channel subunits and (3) incorporation of regulatory subunits to the functional channel complex. In this review article we will focus on one of these mechanisms, alternative pre-mRNA splicing, in the context of the TRP superfamily of cation channels. For this purpose, the basic principles governing pre-mRNA splicing will be introduced and comprehensive tables classifying only published spliced-variants of TRP channels will be presented. (c) 2006 Elsevier Ltd. All rights reserved.
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