Journal
PLANTA MEDICA
Volume 72, Issue 15, Pages 1427-1430Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2006-951711
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Chemical exploration of Carrichaya calcarea (family Compositae) has led to the isolation of nine known sesquiterpene lactones 1 9, together with caffeic acid methyl ester 10. Sesquiterpenes 1, 2, 3, 4, 5, 7, and 8 exhibited moderate antiplasmodial activity, but showed potent antimycobacterial activity. Interestingly, the cytotoxicity of sesquiterpene lactones 1, 2, and 4 towards small-cell lung cancer cell line (NCl-H187) is stronger (two orders of magnitude) than towards the Vero cell line. Caffeic acid methyl ester (10) was cytotoxic against NCl-H187 and BC cell lines, however the ester 10 showed only mild anti mycobacterial activity.
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