Journal
AMERICAN JOURNAL OF HYPERTENSION
Volume 19, Issue 12, Pages 1199-1205Publisher
OXFORD UNIV PRESS
DOI: 10.1016/j.amjhyper.2006.05.001
Keywords
arterial stiffness; pulse wave velocity; left ventricular hypertrophy; electrocardiography
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Background: Whether arterial stiffness per se contributes to left ventricular hypertrophy (LVH) independently of blood pressure (BP) remains unknown. We examined the relationship between pulse wave velocity (PWV) and LVH in a large population. Methods: The PWV was measured between the brachial and ankle regions (baPWV) of 798 individuals. We diagnosed LVH using electrocardiographic criteria: Cornell voltage-duration product > 2440 mm X msec or Sokolow-Lyon voltage > 38 mm. The participants were initially separated into those with and without LVH [LVH(+) and LVH(-) groups, respectively. To determine theoretical baPWV, we first constructed a nomogram for the LVH(-) group, calculated the PWV index (measured baPWV - theoretical baPWV) for each individual and then compared the two groups. We also examined the factors associated with LVH(+) using multivariate analyses. Results: Linear regression analysis revealed that the theoretical baPWV (m/sec) = 0.20 X age (years) + 0.13 X Mean arterial pressure (MAP) (mm Hg) + 0.05 X Heart rate (beats/min) - 11.74 (R 2 = 0.56). The PWV index was greater in the LVH(+) than in the LVH(-) group (P =.025). The baPWV was independently related to LVH(+) along with MAP, medication for hypertension, and for diabetes; a I SD (4.3 m/sec) increase in baPWV was associated with a 26% increase in the risk of LVH(+) (P =.022). When LVH(+) risk factors were defined as hypertension, diabetes, and high baPWV ( >= 14.6 m/sec), the prevalence of LVH(+) linearly increased with the number of concomitant LVH(+) risk factors (P <.001). Conclusions: Arterial stiffness is independently related to electrocardiographically determined LVH in the general population.
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