Journal
BIOMETALS
Volume 19, Issue 6, Pages 633-635Publisher
SPRINGER
DOI: 10.1007/s10534-006-9000-8
Keywords
African siderosis; hemochromatosis; HIV infection; iron loading; lactoferrin; osteoblasts; osteoclasts; osteoporosis; sickle cell anemia; tea catechins; thalassemia
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Iron loaded persons are at increased risk for infection, neoplasia, arthropathy, cardiomyopathy and an array of endocrine and neurodegenerative diseases. This report summarizes evidence of increased risk of iron loading for osteoporosis. Iron suppresses bone remodeling apparently by decreasing osteoblast formation and new bone synthesis. Low molecular mass iron chelators as well as a natural protein iron chelator, lactoferrin, may be useful in prevention of osteoporosis.
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