Journal
NEUROPSYCHOPHARMACOLOGY
Volume 31, Issue 12, Pages 2783-2792Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.npp.1301166
Keywords
sleep deprivation; recovery; PET; frontal lobe
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We studied the effects of total sleep deprivation and recovery sleep in normal subjects using position emission tomography with 18F-deoxyglycose. Sleep deprivation resulted in a significant decrease in relative metabolism of the frontal cortex, thalamus, and striatum. Recovery sleep was found to have only a partial restorative effect on frontal lobe function with minimal reversal of subcortical deficits. Sleep may be especially important for maintenance of frontal lobe activity.
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