Journal
CELL MOTILITY AND THE CYTOSKELETON
Volume 63, Issue 12, Pages 741-746Publisher
WILEY-LISS
DOI: 10.1002/cm.20159
Keywords
flagellum; bend initiation; bend propagation; axoneme; dynein; trypanosome
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Motility in trypanosomes is achieved through the undulating behaviour of a single 9 + 2 flagellum; normally the flagellar waves begin at the flagellar tip and propagate towards the base. For flagella in general, however, propagation is from base-to-tip and it is believed that bend formation, and sustained regular oscillation, depend upon a localised resistance to inter-doublet sliding - which is normally conferred by structures at the flagellar base, typically the basal body. We therefore predicted that in trypanosomes there must be a resistive structure at the flagellar tip. Electron micrographs of Crithidia deanei, Herpetomonas megaseliae, Trypanosoma brucei and Leishmania major have confirmed that such attachments are present. Thus, it can be assumed that in trypanosomes microtubule sliding at the flagellar tip is resisted sufficiently to permit bend fort-nation.
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