Journal
JOURNAL OF CLINICAL VIROLOGY
Volume 37, Issue -, Pages S57-S62Publisher
ELSEVIER
DOI: 10.1016/S1386-6532(06)70013-0
Keywords
HHV-6; multi-virus array; central nervous system; post-bone marrow transplant
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Background: HHV-6 has been implicated in a number of neurological disorders. Recent evidence has suggested high incidence of HHV-6 infection in patients (46%) undergoing allogeneic bone marrow transplant (BMT). Objective: To investigate whether HHV-6 plays a role in the development of fatal encephalopathy in an allogeneic post-BMT patient using an unbiased approach. Results: Detection of HHV-6 viral DNA sequence and RNA expression were demonstrated in fresh frozen post-mortem autopsy material derived from the insular cortex using a multi-virus array platform. In addition, PCR analysis by real-time quantitative TaqMan demonstrated high viral burden in multiple brain regions tested. Sequencing analysis of PCR product confirmed the virus to be HHV-6 variant B. Conclusions: Active infection as demonstrated by expression of viral RNA and high viral load in the CNS suggest a possible pathogenic role of HHV-6 in development neurologic complications post-BMT. (c) 2006 Elsevier B.V. All rights reserved.
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