Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 29, Issue 12, Pages 2510-2513Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.29.2510
Keywords
Sauropus androgynus; 3-O-beta-D-glucosyl-(1 -> 6)-beta-D-glucosyl-kaempferol; body weight; weight reduction; anti-obesity
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The young sticks and leaves of Sauropus androgynus (SA) that had been used as a health food for body weight reduction, led to an outbreak of obliterative bronchiolitis in Taiwan. This study tested the toxicity and anti-obesity features of the SA-isolated compound, 3-O-beta-D-glucosyl-(1 -> 6)-beta-D-glucosyl-kaempferol (GGK), on male Wistar rats receiving 6 or 60 mg/kg of GGK orally as well as partial purified EtOAc and n-BuOH fractions of SA extract daily for 28 d. Sixty milligrams per kilogram GGK treatment significantly reduced food intake in rats by 15% (p < 0.05). The reduced food intake corresponded to decreases in body weight in the high or low dose GGK groups, as compared to the control groups. The serum levels of free triglyceride significantly decreased in GGK-treated rats. GGK treatment led to succesive reductions in daily food intake and body weight without obvious histopathological changes in Wistar rats. Thus, GGK may be potentially to be developed as a safe and novel compound for anti-obesity treatment.
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