Journal
ARCHIVES OF ORAL BIOLOGY
Volume 51, Issue 12, Pages 1150-1155Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2006.06.008
Keywords
Langerhans cell; oral mucosa; gingival epithelium; human
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Dendritic cells (DCs) are the professional antigen-presenting cells responsible for initiating of the immune response. Langerhans cells (LCs) are a type of DC that is a permanent resident of the oral epithelium. LCs are organized conforming a network in such a way as to maximize their surface area for efficient apprehension of antigens. To detect age-retated changes in the LCs network, fragments of gingival epithelium spontaneously accompanying dental removals were processed by immunohistochemistry. Monoclonal antibody CD1a followed by biotinized immunoglobulin-streptoavidin peroxidase were used to identify the LCs with the light microscope. LC density and LC types were analyzed according to their morphology and intraepithelial distribution. In the older age group (61-74 years) the density was significantly tower than in the younger age groups. Morphologically, LCs showed fewer dendritic-branching processes and had a rounded shape in the older age group. Present observations indicate that the LC network changes markedly with aging. These results suggest that immunological defense of the oral tissue might be compromised in old age. (c) 2006 Elsevier Ltd. All rights reserved.
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