Journal
NATURAL PRODUCT RESEARCH
Volume 20, Issue 14, Pages 1283-1289Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410601101829
Keywords
Coprinus micaceus; micaceol; (Z,Z)-4-oxo-2,5-heptadienedioic acid; glutathione S-transferase
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Chemical studies on the crude methanolic extract of Coprinus micaceus, collected from the Canadian Prairie region, have resulted in the isolation of two new natural products, micaceol (1), a sterol and (Z,Z)-4-oxo-2,5-hetpadienedioic acid (2). Compound 2 was isolated for the First time as a natural product. Structures of these new compounds were established with the aid of extensive NMR spectroscopic studies. Compound 1 has shown anti-bacterial activity against Corynebacterium xerosis and Staphylococcus aureus, whereas compound 2 exhibited glutathione S-transferase inhibition.
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