Journal
MOLECULAR BIOLOGY AND EVOLUTION
Volume 23, Issue 12, Pages 2268-2270Publisher
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msl105
Keywords
microsatellite; Y chromosome; mutation rate; haplogroup
Funding
- NIGMS NIH HHS [GM 28016, R01 GM028016] Funding Source: Medline
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Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller.
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