Journal
JOURNAL OF NEUROSCIENCE
Volume 26, Issue 49, Pages 12656-12663Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4023-06.2006
Keywords
cerebellum; deep cerebellar nucleus; eyelid conditioning; learning; plasticity; timing
Categories
Funding
- NIMH NIH HHS [MH57051, MH46904, R01 MH057051, R01 MH046904] Funding Source: Medline
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Evidence that cerebellar learning involves more than one site of plasticity comes from, in part, pavlovian eyelid conditioning, where disconnecting the cerebellar cortex abolishes one component of learning, response timing, but spares the expression of abnormally timed short-latency responses (SLRs). Here, we provide evidence that SLRs unmasked by cerebellar cortex lesions are mediated by an associative form of learning-induced plasticity in the anterior interpositus nucleus (AIN) of the cerebellum. We used pharmacological inactivation and/or electrical microstimulation of various sites afferent and efferent to the AIN to systematically eliminate alternative candidate sites of plasticity upstream or downstream from this structure. Collectively, the results suggest that cerebellar learning is mediated in part by plasticity in target nuclei downstream of the cerebellar cortex. These data demonstrate an instance in which an aspect of associative learning, SLRs, can be used as an index of plasticity at a specific site in the brain.
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