Journal
NEURON
Volume 52, Issue 5, Pages 883-896Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2006.10.010
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Funding
- NIDA NIH HHS [DA15098, R03 DA015098] Funding Source: Medline
- NINDS NIH HHS [R01 NS044185, R01 NS045625, NS045625, NS44185] Funding Source: Medline
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Input-specific long-term potentiation (LTP) in afferent inputs to the amygdala serves an essential function in the acquisition of fear memory. Factors underlying input specificity of synaptic modifications implicated in information transfer in fear conditioning pathways remain unclear. Here we show that the strength of naive synapses in two auditory inputs converging on a single neuron in the lateral nucleus of the amygdala (LA) is only modified when a postsynaptic action potential closely follows a synaptic response. The stronger inhibitory drive in thalamic pathway, as compared with cortical input, hampers the induction of LTP at thalamo-amygdala synapses, contributing to the spatial specificity of LTP in convergent inputs. These results indicate that spike timing-dependent synaptic plasticity in afferent projections to the LA is both temporarily and spatially asymmetric, thus providing a mechanism for the conditioned stimulus discrimination during fear behavior.
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