Journal
ORGANIC LETTERS
Volume 8, Issue 25, Pages 5685-5688Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0618858
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- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0910014] Funding Source: National Science Foundation
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A novel route to the synthesis of cyclopropane derivatives is described. 1,1-Dimethyls in 2-(1,1-dimethylalkyl)dimethyloxazolines are first converted into 1,3-diiodide derivatives via Pd-catalyzed sequential C-H activation and then radically cyclized to provide 2-(1-alkylcylclopropyl)dimethyloxazolines. The use of EtOAc as a solvent is crucial for the diiodination of the functionalized substrates.
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