Journal
CANCER LETTERS
Volume 244, Issue 2, Pages 143-163Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2006.02.017
Keywords
tenascin-C; fibronectin; tumor; cancer; microenvironment; metastasis; angiogenesis; proliferation; genomic instability; invasion; Wnt signaling; DKK1; MAP kinase; FAK; RhoA; tropomyosin; carcinoma associated fibroblast; tumor associated macrophage
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Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed in the microenvironment of most solid tumors. High tenascin-C expression reduces the prognosis of disease-free survival in patients with some cancers. The possible role of tenascin-C in tumor initiation and progression is addressed with emphasis on underlying signaling mechanisms. How tenascin-C affects malignant transformation, uncontrolled proliferation, angiogenesis, metastasis and escape from tumor inummosurveillance is summarized. Finally, we discuss how the phenotypes of tenascin-C knock-out mice may help define the roles of tenascin-C in tumorigenesis and how this knowledge could be applied to cancer therapy. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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