Journal
TETRAHEDRON LETTERS
Volume 47, Issue 50, Pages 8921-8924Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.10.055
Keywords
hydroxybiaryl; Suzuki cross-coupling; palladium catalyst; arylboronic acid; microwave
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In this letter we report a simple and efficient way for the direct Suzuki-Miyaura cross-coupling of unprotected 2-hydroxyaryl bromides and of 2-chlorophenol with arylboronic acids using suitable phosphine/Pd(OAC)2 catalysts systems with moist K3PO4/toluene or moist CsF/dioxane and microwave heating (20 min 105 degrees C to 3 It 100-120 degrees C) with an internal temperature control providing 2-hydroxybiaryls in yields up to 98%. (c) 2006 Elsevier Ltd. All rights reserved.
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