4.4 Article

A novel ruthenium-catalyzed amination of primary and secondary alcohols

Journal

TETRAHEDRON LETTERS
Volume 47, Issue 50, Pages 8881-8885

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2006.10.042

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An improved method for the N-alkylation of primary amines with primary and secondary alcohols has been developed. Novel, effective catalyst systems, for example, RU3(CO)(12) combined with tri-o-tolylphosphine or n-butyl-di-1-adamantylphosphine, allow for aminations in a good yield under comparatively mild conditions. (c) 2006 Elsevier Ltd. All rights reserved.

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