Journal
NANO LETTERS
Volume 6, Issue 12, Pages 2899-2903Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl062183e
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Funding
- NIGMS NIH HHS [R37 GM029554-26, R37 GM029554, R01 GM029554, GM-29554, R37 GM029554-25, R37 GM029554-24] Funding Source: Medline
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The PX-JX(2) device is a robust sequence-dependent DNA nanomachine. It is controlled by the addition of DNA strands to the solution. The ability to control such devices with RNA will enable the machine to respond to signals generated by transcriptional logic circuits in vitro or, possibly, in vivo. The PX-JX(2) device does not respond properly to RNA strands, so we have adapted the signaling method by using a cover-strand strategy, This approach entails using DNA control strands that contain sequence regions to set the device to either state. An RNA strand is used to mask one of these two regions, enabling the machine to assume the state corresponding to the unmasked region.
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