Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 120, Issue 1, Pages 187-193Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2006.02.006
Keywords
optical biosensor; low-k dielectric; micro-replication; FDTD; direct assay; photonic crystal
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The sensitivity of a photonic crystal optical biosensor is greatly enhanced through the incorporation of low refractive index porous dielectric material into the device structure. In this work, computer models are used to predict the reflectance spectra and sensitivity performance of a one-dimensional photonic crystal biosensor. A manufacturable replication method is demonstrated that can produce a low-index dielectric periodic surface structure with a 550 mu period over large surface areas. The sensitivity of porous glass biosensors is characterized and compared with sensors incorporating non-porous polymer material. Results for detection of proteins, polymer layers, and bulk liquids indicate up to a four-fold sensitivity increase. (c) 2006 Elsevier B.V. All rights reserved.
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