Reactivity of cyclometallated platinum complexes with chiral ligands

The reaction of [Pt2Me4(mu-SMe2)(2)] with 3-substituted iminic thiophenes and 2-phenylpyridine gives platinum (11) [C,N] cyclometallated complexes which contain a labile ligand (SMe2 or CH3CN). Several platinum (II) complexes have been synthesized by substitution reactions with phosphine or sulfoxide ligands to introduce, in most cases, a second chiral center. The new complexes' reactions with methyl iodide were subsequently studied and showed results that are dependent on the steric and electronic effects of both the cyclometallated ligand and the ancillary phosphine or sulfoxide ligand. The structure of [PtMe((R)-C10H7CHMeNCHC4H2S)(CH3CN)], a synthetic precursor, is also reported. (c) 2006 Elsevier B.V. All rights reserved.