New compounds via Mannich reaction of cytosine, paraformaldehyde and cyclic secondary amines

The Mannich reaction of cytosine, paraformaldehyde and cyclic secondary amines in the presence of acetic acid gives 5-(4'-morpholinyl)methylcytosine, 5-(1'-piperidinyl)methylcytosine, 5-(1-pyrrolidinyl)methylcytosine, 5-(4'-methyl-1'-piperidinyl)methylcytosine, 5-(3-methyl-1'-piperidinyl)methylcyto sine and 5-(2'-methyl-1'-piperidinyl)methylcytosine. These products are quite different from those obtained via cytosine aminomethylation previously described in the literature. (c) 2006 Elsevier Ltd. All rights reserved.