Journal
BRAIN RESEARCH
Volume 1126, Issue -, Pages 183-187Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2006.07.016
Keywords
hippocampus; phytoestrogen; prefrontal cortex; recognition memory; spatial memory
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Funding
- NCRR NIH HHS [G12-RR-TT03037] Funding Source: Medline
- NIGMS NIH HHS [S06 GM60654, 2T34 GM007823, R25 GM60665] Funding Source: Medline
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Long-term maintenance of ovariectornized rats (9weeks) on chow containing high phytoestrogen levels (Purina LabDiet (R) 5001) as compared to chow with minimal phytoestrogens (Harlan 2016 Teklad) was associated with better performance of the spatial memory task, object placement, increased dendritic spine density in CA1 and prefrontal cortex pyramidal neurons, and higher uterine weights. Object recognition memory, anxiety on an elevated plus maze and body weight were unaffected by phytoestrogen levels in the diet. (c) 2006 Elsevier B.V. All rights reserved.
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