4.8 Article

Total synthesis of phorboxazole A. 1. Preparation of four subunits

Journal

ORGANIC LETTERS
Volume 8, Issue 26, Pages 6039-6042

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol062530r

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Funding

  1. NIGMS NIH HHS [GM-50574, GM-58889] Funding Source: Medline

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Four subunits of the potent antitumor agent phorboxazole A were constructed; fragments C20-C32 and C9-C19 containing tetrahydropyrans A and B, respectively, were assembled using palladium-catalyzed intramolecular alkoxycarbonylation.

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