Journal
ORGANIC LETTERS
Volume 8, Issue 26, Pages 6007-6010Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0624878
Keywords
-
Categories
Funding
- PHS HHS [13598] Funding Source: Medline
Ask authors/readers for more resources
Enantiospecific aliphatic Claisen rearrangement was realized with generally high chirality transfer. The requisite substrates were synthesized via Pd-catalyzed asymmetric allylic alkylation ( AAA) from easily obtained starting materials. After protection, the resultant bisallyl ethers underwent olefin isomerization and in situ Claisen rearrangement ( ICR) to generate r- chiral aldehydes. Remarkable chemoselectivity in the olefin isomerization step was observed. An asymmetric synthesis of communiol A was accomplished applying this methodology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available