Journal
FEBS LETTERS
Volume 580, Issue 30, Pages 6938-6942Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2006.11.059
Keywords
genome stability; RecQ; helicase; repair; Drosophila melanogaster
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Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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