Journal
SCIENCE
Volume 314, Issue 5807, Pages 1941-1944Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1132009
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Funding
- Medical Research Council [G0600678] Funding Source: Medline
- Medical Research Council [G0600678] Funding Source: researchfish
- MRC [G0600678] Funding Source: UKRI
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Many species express endogenous cycles in physiology and behavior that allow anticipation of the seasons. The anatomical and cellular bases of these circannual rhythms have not been defined. Here, we provide strong evidence using an in vivo Soay sheep model that the circannual regulation of prolactin secretion, and its associated biology, derive from a pituitary-based timing mechanism. Circannual rhythm generation is seen as the product of the interaction between melatonin-regulated timer cells and adjacent prolactin- secreting cells, which together function as an intrapituitary pacemaker-slave timer system. These new insights open the way for a molecular analysis of long-term timing mechanisms.
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