Journal
POLYHEDRON
Volume 25, Issue 18, Pages 3457-3462Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2006.06.039
Keywords
gallium; DOTA; X-ray structure; TGA
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As part of our efforts to synthesize gallium bioconjugates based on folic acid and thiamin we have utilized 1,4,7,10-tetraazacyclododecane-N,N',N,N'-tetraacetic acid (DOTA) as the chelating ligand for gallium(III). The reaction of gallium chloride with POTA at room temperature in aqueous solution affords the complex [Ga(HDOTA) center dot 5.5H(2)O] (1), which is characterized by single-crystal X-ray spectroscopy, electrospray mass spectrometry and thermal gravimetric analysis. Gallium displays 6-coordinate distorted octahedral geometry within a puckered macrocyclic DOTA framework. The equatorial plane comprises two nitrogens of the DOTA ring and two oxygens from two of the four pendant carboxylic acid groups. The axial positions are comprised of the remaining two transarmular nitrogens of the DOTA ring. (c) 2006 Elsevier Ltd. All rights reserved.
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