Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 103, Issue 52, Pages 19848-19853Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0609635104
Keywords
cancer; stroma; microarray
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Funding
- NCI NIH HHS [5R01 CA078544-07, R01 CA078544] Funding Source: Medline
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The interactions between cancer cells and the surrounding host stromal tissue play a critical role in tumor progression and metalstasis, but the molecular nature of this relationship remains largely uncharacterized. Furthermore, although genetic changes of neoplastic cells in tumors contribute significantly to tumor progression, it is not known whether similar changes occur in the adjacent host stromal microenvironment and whether they contribute to or inhibit tumorigenesis. To address this question in an unbiased and genome-wide manner, we applied high-resolution DNA copy number analysis to murine stromal DNA isolated from human xenograft tumors that were formed in immunodeficient mice. We show that numerous amplifications and deletions are found within the host stromal microenvironment, suggesting that alterations in host DNA copy number can occur and may play a significant role in modifying tumor-stromal interactions.
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