Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 58, Issue 15, Pages 1688-1713Publisher
ELSEVIER
DOI: 10.1016/j.addr.2006.09.017
Keywords
nanoparticles; freeze-drying; stability; freezing; cryoprotectant; glass transition; physical and chemical characterization; formulation
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Freeze-drying has been considered as a good technique to improve the long-term stability of colloidal nanoparticles. The poor stability in an aqueous medium of these systems forms a real barrier against the clinical use of nanoparticles. This article reviews the state of the art of freeze-drying nanoparticles. It discusses the most important parameters that influence the success of freeze-drying of these fragile systems, and provides an overview of nanoparticles freeze-drying process and formulation strategies with a focus on the impact of formulation and process on particle stability. (c) 2006 Elsevier B.V. All rights reserved.
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