Journal
CHEMICAL SOCIETY REVIEWS
Volume 36, Issue 10, Pages 1674-1689Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b701444a
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Funding
- NIGMS NIH HHS [GM 076261] Funding Source: Medline
- NIMH NIH HHS [MH 070040] Funding Source: Medline
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This critical review concerns the impact of copper-mediated alkyne-azide cycloadditions on peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into peptide chains, to link peptides to other functionalities ( e. g. carbohydrates, polymers, and labels), and as a basis for evolution of less peptidic compounds as pharmaceutical leads. It will be of interest to those studying this click reaction, peptidomimetic secondary structure and function, and to medicinal chemists.
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