Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 13, Issue 22, Pages 6452-6460Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200700177
Keywords
buflavine; cross-coupling; medium-sized rings; metathesis; microwave irradiation
Categories
Ask authors/readers for more resources
Two novel and efficient strategies for the synthesis of hitherto unknown N-shifted and ring-expanded buflavine analogues are presented. Construction of the medium-sized ring system of the title molecules, a difficult task due to the high activation energy needed for the ring-closure with the additional rigidity imposed by the biaryl skeleton, was achieved by using Suzuki-Miyaura biaryl coupling and a ring-closing metathesis reaction as the key steps. The combination of a second-generation Grubbs catalyst and microwave irradiation proved to be highly useful in generating the otherwise difficult to obtain medium-sized ring system of the buflavine analogues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available