Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 986-1007Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2119
Keywords
Parkinson's disease; Huntington's disease; rotenone; 3-NPA; isoquinolines; review
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The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA).
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