Journal
ARTHRITIS RESEARCH & THERAPY
Volume 9, Issue -, Pages -Publisher
BMC
DOI: 10.1186/ar2170
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Funding
- NIAMS NIH HHS [AR49192, R01 AR049192, R01 AR047443, AR47096, AR47443] Funding Source: Medline
- NIDCR NIH HHS [R01 DE013754, DE13754] Funding Source: Medline
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Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant- associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant- bone interface is manifested by recruitment of a wide array of cell types. These cells include macrophages, fibroblasts, giant cells, neutrophils, lymphocytes, and - most importantly - osteoclasts, which are the principal bone resorbing cells. The 'cellular response' entails secretion of osteoclastogenic and inflammatory cytokines that favor exacerbated osteoclast activity and enhanced osteolysis. An appreciation of the complex network that leads to these cellular and inflammatory responses will form a foundation on which to develop therapeutic interventions to combat inflammatory periprosthetic bone loss.
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