Journal
PARKINSONISM & RELATED DISORDERS
Volume 13, Issue 6, Pages 369-371Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2006.07.011
Keywords
Parkinson's disease; pathological gambling; dopaminergic therapy; subthalamic nucleus deep brain stimulation
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We describe two patients with Parkinson's disease (PD) who developed clinical criteria of pathological gambling addiction in the setting of increased dopamine replacement therapy (levodopa and dopamine agonist medications). The second patient showed also signs of dopamine dysregulation syndrome, with an addiction to dopaminergic medication. Neither patients responded to the standard therapy for gambling behavior, but dramatically improved after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) and early postoperative withdrawal of dopaminergic therapy. The possible therapeutic role of subthalamic nucleus deep brain Stimulation (STN-DBS) on such a disabling behavior needs to be investigated prospectively. (c) 2006 Elsevier Ltd. All rights reserved.
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