Journal
ANIMAL GENETICS
Volume 41, Issue 1, Pages 109-112Publisher
WILEY
DOI: 10.1111/j.1365-2052.2009.01969.x
Keywords
ASIP; ATRN; coat colour; color; DEFB103; MC1R; MTNR1A; pigmentation
Funding
- DairyGen
- Natural Science and Engineering Research Council
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P>The variant red phenotype in Holstein cattle is indistinguishable from the traditional e/e recessive red phenotype caused by a mutation in melanocortin 1 receptor, but is inherited as a dominant trait in relation to black. Co-segregation analysis in four half-sib families segregating for variant red was conducted, excluding melanocortin 1 receptor, agouti signalling protein, attractin and melatonin receptor 1A as causative genes. However, variant red co-segregated with markers in a region of BTA27 that includes beta-defensin 103 (DEFB103). Two newly identified microsatellites and 5 SNPs 5' of DEFB103 were used for linkage mapping in four segregating families (LOD = 3.26). One haplotype was inherited in VR cattle in a 6-generation pedigree.
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