Journal
GENOME BIOLOGY
Volume 8, Issue 11, Pages -Publisher
BMC
DOI: 10.1186/gb-2007-8-11-r253
Keywords
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Funding
- NIDDK NIH HHS [U01 DK062418] Funding Source: Medline
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We have developed an integrative analysis method combining genetic interactions, identified using type l diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/ proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.
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