Journal
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
Volume 21, Issue 24, Pages 3977-3981Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/rcm.3302
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A matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry method for rapidly enumerating hydroxyl groups in analytes is described, and applied to some common polyalcohols (erythritol, mannitol and xylitol). Polyalcohols were derivatized with trimethylsilylimidazole (TMSI) either separately or as mixtures, and were analyzed, without chromatographic separation or purification. The mass spectra revealed consecutive peaks that are separated by 72 m/z units as a consequence of displacement of one hydroxyl hydrogen atom by one TMS group. The number of observed peaks was used to confirm the number of hydroxyl groups in each analyte. Published in 2007 by John Wiley & Sons, Ltd.
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