Journal
MEDIATORS OF INFLAMMATION
Volume 2007, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2007/45794
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Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis. Subject and methods. Eighteen subjects were divided in two groups: experimental ( age 52.9 +/- 5.0) and control ( age 51.1 +/- 9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione ( GSSG), thiobarbituric acid reactive substances (TBARS), andmyeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student t test andP <.05. Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group ( P <.05). Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.
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