Gadolinium deposition in nephrogenic fibrosing dermopathy

There is growing recognition of the association between the use of gadolinium-containing radiocontrast agents for magnetic resonance imaging and the serious dermal and systemic disease nephrogenic fibrosing dermopathy/nephrogenic Systemic fibrosis (NFD/NSF), The pathogenesis of this entity remains unclear, however, our recent observations Suggest a likely mechanism for the initial dermal manifestations of this gadolinium toxicity.