Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 13, Issue 5, Pages 1594-1601Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200601155
Keywords
amines; carbenes; carbonylation; hydroaminomethylation; pharmaceuticals; rhodium
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Starting from [jRh(cod)Cl)21 and 1,3-dimesitylimidazole-2-ylidenes the novel [RhCl(cod)(carbene)] complexes 1-5 have been synthesized, characterized, and tested in the hydroaminomethylation of aromatic olefins. The influence of different ligands and reaction parameters on the catalytic activitywas investigated in detail applying 1,1diphenylethylene and piperidine as a model system. The scope and limitations of the novel catalysts is shown in the preparation of 16 biologically active 1-amino-3,3-diarylpropenes. In general, high chemo- and regioselectivity as well as good yields of the desired products were achieved.
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