Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 19, Issue -, Pages 89-119Publisher
WILEY
DOI: 10.1111/j.1365-2982.2006.00876.x
Keywords
abdominal pain; drugs; enteric flora; GI disorders; gut; sensitivity; serotonin
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Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity, and the status of current and future drug and probiotic treatment development, and the role of pharmacogenomic factors.
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