Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 12, Issue -, Pages 1946-1955Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2200
Keywords
ciprofloxacin; ctDNA; nano-SnO2; poly(Vinyl) sulfonic potassium; interaction
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In pH 6.0 phosphate buffer solutions ( PBS), a glassy carbon electrode ( GCE) modifying by nano-tin oxide/ poly vinyl sulfonic potassium ( nano- SnO2/ PVS) exhibited an enhanced effectiveness for the oxidation of ciprofloxacin ( CFX), which compared with a bare GCE or a nano- SnO2 modified electrode. In addition we also investigated the electrooxidation mechanism of the fluoroquinolone antibiotics ( utilizing ciprofloxacin, ofloxacin, sparfloxacin and lomefloxacin) at the modified electrode. Further more, Gel electrophoresis coupled with electrochemistry and spectra techniques were used to study the interaction of CFX and calf thymus DNA ( ctDNA). These acquired data showed that the binding mode of CFX and DNA was mainly an intercalation mechanism.
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