Journal
CELL DEATH AND DIFFERENTIATION
Volume 14, Issue 1, Pages 73-78Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4402034
Keywords
caspase; IAP; apoptosis; protease; p35
Categories
Ask authors/readers for more resources
Caspases, key mediators of apoptosis, are a structurally related family of cysteine proteases that cleave their substrates at aspartic acid residues either to cause cell death or to activate cytokines as part of an immune response. They can be controlled upstream by the regulation of signals that lead to zymogen activation, or downstream by inhibitors that prevent them from reaching their substrates. This review specifically looks at caspase inhibitors as distinct from caspase regulators: those produced by the cell itself; those whose genes are carried by viruses; and artificial caspase inhibitors used for research and potentially as therapeutics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available