Journal
CHROMOSOME RESEARCH
Volume 15, Issue 5, Pages 539-550Publisher
SPRINGER
DOI: 10.1007/s10577-007-1145-y
Keywords
chromosome synapsis; Mec 1; meiosis; meiotic progression; meiotic recombination
Funding
- Medical Research Council [MC_U117573806] Funding Source: Medline
- MRC [MC_U117573806] Funding Source: UKRI
- Medical Research Council [MC_U117573806] Funding Source: researchfish
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Budding yeast Mec1, a homolog of mammalian ATR/ATM, is C an essential chromosome-based signal transduction protein. Mec1 is a key checkpoint regulator and plays a critical role in the maintenance of genome stability. Mec1 is also required for meiosis; loss of Mec1 functions leads to a number of meiotic defects includina reduction in recombination, loss of inter-homolog bias, loss of crossover control, and failure in meiotic progression. Here we review currently available data on meiotic defects associated with loss of Mec1 functions and discuss the possibility that Mec1 may participate as a fundamentally positive player in coordinating and promoting basic meiotic chromosomal processes during nonnal meiosis.
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