Journal
PARKINSONISM & RELATED DISORDERS
Volume 13, Issue 6, Pages 348-354Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2007.01.003
Keywords
Parkinson's disease; EEG; dementia; mild cognitive impairment
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Funding
- NIA NIH HHS [AG 019610] Funding Source: Medline
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We sought to define quantitative electroencephalographic (EEG) measures as biomarkers of both early and late cognitive decline in Parkinson's disease (PD). PD subjects classified as cognitively normal (PD-CogNL), mild cognitive impairment (PD-MCI), and dementia (PD-D) were studied. Cognitive status and neuropsychological testing was correlated with background rhythm and frequency band EEG power across five frequency bands. We conclude that global EEG measures have potential use as biomarkers in the study of both early and late cognitive deterioration in PD, including for evaluating its treatment. PD-MCI has mean quantitative EEG characteristics that represent an intermediate electrophysiological state between PD-CogNL and PD-D. (c) 2007 Elsevier Ltd. All rights reserved.
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