Journal
IMMUNOLOGY AND CELL BIOLOGY
Volume 85, Issue 1, Pages 16-23Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.icb.7100009
Keywords
cirrhosis; hepatitis B virus; immunology; immunopathogenesis; innate immunity; T-cells
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Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.
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