Journal
AXON GROWTH AND GUIDANCE
Volume 621, Issue -, Pages 116-133Publisher
SPRINGER-VERLAG BERLIN
DOI: 10.1007/978-0-387-76715-4_9
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During embryonic development, morphogens act as graded positional cues to dictate cell fate specification and tissue patterning. Recent findings indicate that morphogen gradients also serve to guide axonal pathfinding during development of the nervous system. These findings challenge our previous notions about morphogens and axon guidance molecules and suggest that these proteins, rather than having sharply divergent functions, act more globally to provide graded positional information that can be interpreted by responding cells either to specify cell fate or to direct axonal pathfinding. This chapter presents the roles identified for members of three prominent morphogen families-the Hedgehog, Writ and TGF-beta/BMP families in axon guidance, and discusses potential implications for the molecular mechanisms underlying their guidance functions.
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